The incapability of lnterleukin-4 to induce AP-1 activity in murine mast cells

Ellen Chaikin; Imad Hakeem; Ehud Razin

doi:10.1159/000236930

The incapability of lnterleukin-4 to induce AP-1 activity in murine mast cells

Ellen Chaikin
, Imad Hakeem
, Ehud Razin^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The results presented in this study shed new light on the molecular mechanism responsible for the control of interleukin (IL)-3-and IL-4 mediated mast cell proliferation. By measurements of AP-1 DNA-binding activity, it was found that IL-3 induced such activity while IL-4 did not. This difference in the pattern of AP-1 DNA-binding activity induced by each lymphokine indicates the differential involvement of AP-1 in the different proliferative responses of mast cells to IL-3 and IL-4.

Original language	English
Pages (from-to)	57-59
Number of pages	3
Journal	International Archives of Allergy and Immunology
Volume	107
Issue number	1-3
DOIs	https://doi.org/10.1159/000236930
State	Published - 1995

Keywords

4AP-1
Interleukin
Mast Cells

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10.1159/000236930

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title = "The incapability of lnterleukin-4 to induce AP-1 activity in murine mast cells",

abstract = "The results presented in this study shed new light on the molecular mechanism responsible for the control of interleukin (IL)-3-and IL-4 mediated mast cell proliferation. By measurements of AP-1 DNA-binding activity, it was found that IL-3 induced such activity while IL-4 did not. This difference in the pattern of AP-1 DNA-binding activity induced by each lymphokine indicates the differential involvement of AP-1 in the different proliferative responses of mast cells to IL-3 and IL-4.",

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AU - Chaikin, Ellen

AU - Hakeem, Imad

AU - Razin, Ehud

PY - 1995

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N2 - The results presented in this study shed new light on the molecular mechanism responsible for the control of interleukin (IL)-3-and IL-4 mediated mast cell proliferation. By measurements of AP-1 DNA-binding activity, it was found that IL-3 induced such activity while IL-4 did not. This difference in the pattern of AP-1 DNA-binding activity induced by each lymphokine indicates the differential involvement of AP-1 in the different proliferative responses of mast cells to IL-3 and IL-4.

AB - The results presented in this study shed new light on the molecular mechanism responsible for the control of interleukin (IL)-3-and IL-4 mediated mast cell proliferation. By measurements of AP-1 DNA-binding activity, it was found that IL-3 induced such activity while IL-4 did not. This difference in the pattern of AP-1 DNA-binding activity induced by each lymphokine indicates the differential involvement of AP-1 in the different proliferative responses of mast cells to IL-3 and IL-4.

KW - 4AP-1

KW - Interleukin

KW - Mast Cells

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IS - 1-3

ER -

The incapability of lnterleukin-4 to induce AP-1 activity in murine mast cells

Abstract

Keywords

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