The Influence of Chronic Kidney Disease on the Structural and Mechanical Properties of Canine Bone

A. Shipov, R. Shahar, N. Sugar, G. Segev*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: Chronic kidney disease (CKD) is common in companion animals. Secondary hyperparathyroidism is an inevitable consequence of the disease and may have deleterious effect on the bone; however, the information regarding CKD-associated bone abnormalities in companion animals is scarce. Hypothesis/Objectives: Dogs with CKD have decreased bone quality compared to dogs without CKD. Animals: Nine dogs diagnosed with naturally occurring CKD for at least 6 months and 9 age-matched controls. Methods: Dogs with CKD were enrolled and compared to 9 age-, weight-, and sex-matched control dogs with no evidence of CKD. Samples were assessed using light microscopy, mechanical testing, and microcomputed tomography. Variables evaluated included microstructural features such as number, size, and density of Haversian canals, resorption cavities and osteocytic lacunae, bone mineral density, porosity and Young's modulus. Results: Median lacunae size was significantly smaller in the CKD group compared to the control group (P = 0.001). Resorption cavity density was higher in the CKD compared to the control group (10 [8–14] vs. 7 [4–9]/mm2, respectively, P = 0.001). Overall porosity was significantly (2.3-fold) higher in the CKD compared to the control group. There was no difference in Young's moduli between groups. Conclusions and Clinical Importance: Naturally occurring CKD affects bone quality in dogs, but these changes are relatively mild and likely not to be manifested clinically. The duration of the disease in dogs evaluated here is short compared to cats and human patients, likely accounting for the more subtle changes in dogs compared to other species.

Original languageAmerican English
Pages (from-to)280-287
Number of pages8
JournalJournal of Veterinary Internal Medicine
Issue number1
StatePublished - 1 Jan 2018

Bibliographical note

Publisher Copyright:
Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.


  • biomechanics
  • bone
  • chronic kidney disease
  • renal failure
  • skeleton
  • structure


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