TY - JOUR
T1 - The influence of sequential annual vaccination and of DHEA administration on the efficacy of the immune response to influenza vaccine in the elderly
AU - Ben-Yehuda, A.
AU - Danenberg, H. D.
AU - Zakay-Rones, Z.
AU - Gross, D. J.
AU - Friedman, G.
PY - 1998/5/15
Y1 - 1998/5/15
N2 - The present study examined the effect of repeated vaccination and of dehydroepiandrosterone (DHEA) treatment on the immune response to influenza vaccine in elderly subjects. Seventy-one elderly volunteers, aged 61-89 years, enrolled in a prospective randomized, double-blind study to receive either DHEA (50 mg qd p.o. for 4 consecutive days starting 2 days before immunization) or placebo. Antibody response against the three strains of vaccine was measured before and 28 days after vaccination, and compared between previously vaccinated and non-vaccinated subjects. DHEA treatment did not enhance established immunity. A significant decrease in attainment of protective antibody titer (titer of 1:40 or greater) against A/Texas in subjects with non-protective baseline antibody titer was recorded following DHEA treatment compared to placebo (52 vs. 84%, P < 0.05). Post-immunization titers against influenza A strains were significantly higher in those subjects who were never immunized before. Additionally, post-vaccination protective titers against the A/Johannesburg strain were more prevalent in those subjects who were never vaccinated before. The results were not the same for anti-B/Harbin antibodies - repeated vaccination caused a non-significant increase in HI titer in previously vaccinated subjects.
AB - The present study examined the effect of repeated vaccination and of dehydroepiandrosterone (DHEA) treatment on the immune response to influenza vaccine in elderly subjects. Seventy-one elderly volunteers, aged 61-89 years, enrolled in a prospective randomized, double-blind study to receive either DHEA (50 mg qd p.o. for 4 consecutive days starting 2 days before immunization) or placebo. Antibody response against the three strains of vaccine was measured before and 28 days after vaccination, and compared between previously vaccinated and non-vaccinated subjects. DHEA treatment did not enhance established immunity. A significant decrease in attainment of protective antibody titer (titer of 1:40 or greater) against A/Texas in subjects with non-protective baseline antibody titer was recorded following DHEA treatment compared to placebo (52 vs. 84%, P < 0.05). Post-immunization titers against influenza A strains were significantly higher in those subjects who were never immunized before. Additionally, post-vaccination protective titers against the A/Johannesburg strain were more prevalent in those subjects who were never vaccinated before. The results were not the same for anti-B/Harbin antibodies - repeated vaccination caused a non-significant increase in HI titer in previously vaccinated subjects.
KW - Dehydroepiandrosterone (DHEA)
KW - Elderly
KW - Influenza vaccine
UR - http://www.scopus.com/inward/record.url?scp=0032524998&partnerID=8YFLogxK
U2 - 10.1016/S0047-6374(98)00017-7
DO - 10.1016/S0047-6374(98)00017-7
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C2 - 9720660
AN - SCOPUS:0032524998
SN - 0047-6374
VL - 102
SP - 299
EP - 306
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 2-3
ER -