The internal organization of the varicella-zoster virus genome

D. H. Gilden, Y. Shtram, A. Friedmann, M. Wellish, M. Devlin, N. Fraser, Y. Becker

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

DNA was extracted from varicella-zoster (VZ) virions prepared in sucrose gradients. Thirty-eight molecules examined by electron microscopy were found to have a mean lenght of 46.7 μm. Examination of self-annealed VZV DNA molecules revealed that the virus genome was composed of a unique linear large sequence with a mol. wt. of 74.4 x 106 to 78.4 x 106, and a unique short sequence of mol. wt. approx. 9.8 x 106 flanked by inverted repeat sequences of 4.7 x 106 mol. wt.

Original languageEnglish
Pages (from-to)371-374
Number of pages4
JournalUnknown Journal
Volume60
Issue number2
DOIs
StatePublished - 1982

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