The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis

Karina Yaniv, Joel K. Yisraeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Vg1 RBP is a member of a family of highly conserved proteins that appear to be involved in RNA localization, stability, and/or translational control in a wide variety of cell types and organisms. Over the last few years, the human homologs of these proteins have been found to be overexpressed in an increasing number of different kinds of cancers. Although the role of these proteins in neoplasia is not understood, results from several labs, including our own, are beginning to suggest that many of these proteins may be important in cell motility, a necessary requirement for metastasis. This paper will review these data and suggest a model for the role of Vg1 RBP and its homologs in embryonic development and carcinogenesis.

Original languageAmerican English
Pages (from-to)49-54
Number of pages6
JournalGene
Volume287
Issue number1-2
DOIs
StatePublished - 3 Apr 2002

Bibliographical note

Funding Information:
We would like to thank Yuri Oleynikov, Rob Singer, and Gary Bassell for sharing with us unpublished results. Different parts of this work were funded by grants from the US-Israel Binational Science Foundation (BSF), the Israel Science Foundation, and the Israel Cancer Research Fund (ICRF).

Keywords

  • Cell motility
  • Intracellular RNA localization
  • Metastasis

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