TY - JOUR
T1 - The Iron State in Spleen and Liver Tissues from Patients with Hematological Malignancies Studied Using Magnetization Measurements and Mössbauer Spectroscopy
AU - Alenkina, I. V.
AU - Vinogradov, A. V.
AU - Felner, I.
AU - Konstantinova, T. S.
AU - Kuzmann, E.
AU - Semionkin, V. A.
AU - Oshtrakh, M. I.
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/3/15
Y1 - 2019/3/15
N2 - In this overview, we present the results of the study of spleen and liver tissues taken from healthy donors in comparison with those from patients with (i) non-Hodgkin B-cell lymphomas, namely, mantle cell lymphoma and marginal zone B-cell lymphoma, (ii) acute myeloid leukemia, and (iii) primary myelofibrosis. The study was carried out using Mössbauer spectroscopy and magnetization measurements for the analysis of ferritin-like iron in spleen and liver tissues. Magnetization measurements demonstrated small differences in the saturation magnetic moments and revealed additional paramagnetic components. Two liver samples demonstrated unusual behavior of the magnetic moment when the zero-field-cooled curve was over the field-cooled curve in the temperature range between ~40 and ~70 K. Relative iron content variations in the tissue cells as well as small variations in the 57 Fe hyperfine parameters were demonstrated for healthy and patients’ spleen and liver tissues on the base of measured Mössbauer spectra. The results obtained permit us to suggest small differences in the ferritin iron core structure in spleen and liver tissues from healthy donors and patients with hematological malignancies.
AB - In this overview, we present the results of the study of spleen and liver tissues taken from healthy donors in comparison with those from patients with (i) non-Hodgkin B-cell lymphomas, namely, mantle cell lymphoma and marginal zone B-cell lymphoma, (ii) acute myeloid leukemia, and (iii) primary myelofibrosis. The study was carried out using Mössbauer spectroscopy and magnetization measurements for the analysis of ferritin-like iron in spleen and liver tissues. Magnetization measurements demonstrated small differences in the saturation magnetic moments and revealed additional paramagnetic components. Two liver samples demonstrated unusual behavior of the magnetic moment when the zero-field-cooled curve was over the field-cooled curve in the temperature range between ~40 and ~70 K. Relative iron content variations in the tissue cells as well as small variations in the 57 Fe hyperfine parameters were demonstrated for healthy and patients’ spleen and liver tissues on the base of measured Mössbauer spectra. The results obtained permit us to suggest small differences in the ferritin iron core structure in spleen and liver tissues from healthy donors and patients with hematological malignancies.
KW - Ferritin-like iron
KW - Magnetization measurements
KW - Mössbauer spectroscopy
KW - Non-Hodgkin B-cell lymphoma, primary myelofibrosis, and acute myeloid leukemia
KW - Spleen and liver tissues
UR - http://www.scopus.com/inward/record.url?scp=85053476723&partnerID=8YFLogxK
U2 - 10.1007/s12013-018-0855-4
DO - 10.1007/s12013-018-0855-4
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C2 - 30191452
AN - SCOPUS:85053476723
SN - 1085-9195
VL - 77
SP - 33
EP - 46
JO - Cell Biochemistry and Biophysics
JF - Cell Biochemistry and Biophysics
IS - 1
ER -
