The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Simon D. Harding*, Elena Faccenda, Christopher Southan, Adam J. Pawson, Pasquale Maffia, Stephen P.H. Alexander, Anthony P. Davenport, Doriano Fabbro, Francesca Levi-Schaffer, Michael Spedding, Jamie A. Davies

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Given the critical role that the immune system plays in a multitude of diseases, having a clear understanding of the pharmacology of the immune system is crucial to new drug discovery and development. Here we describe the International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb), which connects expert-curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. In the pursuit of new therapeutics, pharmacological databases are a vital resource to researchers through providing accurate information on the fundamental science underlying drug action. This extension to the existing IUPHAR/British Pharmacological Society Guide to Pharmacology supports research into the development of drugs targeted at modulating immune, inflammatory or infectious components of disease. To provide a deeper context for how the resource can support research we show data in GtoImmuPdb relating to a case study on the targeting of vascular inflammation.

Original languageAmerican English
Pages (from-to)10-23
Number of pages14
JournalImmunology
Volume160
Issue number1
DOIs
StatePublished - 1 May 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Immunology published by John Wiley & Sons Ltd.

Keywords

  • database
  • immune-therapeutics
  • immunopharmacology
  • pharmacology

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