Given the critical role that the immune system plays in a multitude of diseases, having a clear understanding of the pharmacology of the immune system is crucial to new drug discovery and development. Here we describe the International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb), which connects expert-curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. In the pursuit of new therapeutics, pharmacological databases are a vital resource to researchers through providing accurate information on the fundamental science underlying drug action. This extension to the existing IUPHAR/British Pharmacological Society Guide to Pharmacology supports research into the development of drugs targeted at modulating immune, inflammatory or infectious components of disease. To provide a deeper context for how the resource can support research we show data in GtoImmuPdb relating to a case study on the targeting of vascular inflammation.
Bibliographical noteFunding Information:
The authors wish to thank the grant holders and scientific advisors for the Guide to Immunopharmacology not already listed on this manuscript: Prof. Clare Bryant and Prof. Steve Anderton. The authors appreciate the contributions made by Prof. Adriano G. Rossi, Dr Georgia Perona-Wright and the IUPHAR Immunopharmacology Section (https://iuphar.org/sections-subcoms/immunopharmacology/). We also would like to acknowledge Joanna L. Sharman for database development advice and support. Thanks also to the members of Immunopaedia: Prof. Clive Gray, Prof. Michelle Letarte and Bon Holtak. This work was funded by the Wellcome Trust (108420/Z/15/Z); the International Union of Basic and Clinical Pharmacology; and the British Pharmacological Society (MED791).
© 2020 The Authors. Immunology published by John Wiley & Sons Ltd.