The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Simon D. Harding; Elena Faccenda; Christopher Southan; Adam J. Pawson; Pasquale Maffia; Stephen P.H. Alexander; Anthony P. Davenport; Doriano Fabbro; Francesca Levi-Schaffer; Michael Spedding; Jamie A. Davies

doi:10.1111/imm.13175

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Simon D. Harding^*, Elena Faccenda, Christopher Southan, Adam J. Pawson, Pasquale Maffia, Stephen P.H. Alexander, Anthony P. Davenport, Doriano Fabbro, Francesca Levi-Schaffer, Michael Spedding, Jamie A. Davies

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Given the critical role that the immune system plays in a multitude of diseases, having a clear understanding of the pharmacology of the immune system is crucial to new drug discovery and development. Here we describe the International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb), which connects expert-curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. In the pursuit of new therapeutics, pharmacological databases are a vital resource to researchers through providing accurate information on the fundamental science underlying drug action. This extension to the existing IUPHAR/British Pharmacological Society Guide to Pharmacology supports research into the development of drugs targeted at modulating immune, inflammatory or infectious components of disease. To provide a deeper context for how the resource can support research we show data in GtoImmuPdb relating to a case study on the targeting of vascular inflammation.

Original language	English
Pages (from-to)	10-23
Number of pages	14
Journal	Immunology
Volume	160
Issue number	1
DOIs	https://doi.org/10.1111/imm.13175
State	Published - 1 May 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Immunology published by John Wiley & Sons Ltd.

Keywords

database
immune-therapeutics
immunopharmacology
pharmacology

Access to Document

10.1111/imm.13175

Cite this

@article{930b30c8d5da405ab42413f07e66f8ec,

title = "The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology",

abstract = "Given the critical role that the immune system plays in a multitude of diseases, having a clear understanding of the pharmacology of the immune system is crucial to new drug discovery and development. Here we describe the International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb), which connects expert-curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. In the pursuit of new therapeutics, pharmacological databases are a vital resource to researchers through providing accurate information on the fundamental science underlying drug action. This extension to the existing IUPHAR/British Pharmacological Society Guide to Pharmacology supports research into the development of drugs targeted at modulating immune, inflammatory or infectious components of disease. To provide a deeper context for how the resource can support research we show data in GtoImmuPdb relating to a case study on the targeting of vascular inflammation.",

keywords = "database, immune-therapeutics, immunopharmacology, pharmacology",

author = "Harding, {Simon D.} and Elena Faccenda and Christopher Southan and Pawson, {Adam J.} and Pasquale Maffia and Alexander, {Stephen P.H.} and Davenport, {Anthony P.} and Doriano Fabbro and Francesca Levi-Schaffer and Michael Spedding and Davies, {Jamie A.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Immunology published by John Wiley & Sons Ltd.",

year = "2020",

month = may,

day = "1",

doi = "10.1111/imm.13175",

language = "אנגלית",

volume = "160",

pages = "10--23",

journal = "Immunology",

issn = "0019-2805",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "1",

}

TY - JOUR

T1 - The IUPHAR Guide to Immunopharmacology

T2 - connecting immunology and pharmacology

AU - Harding, Simon D.

AU - Faccenda, Elena

AU - Southan, Christopher

AU - Pawson, Adam J.

AU - Maffia, Pasquale

AU - Alexander, Stephen P.H.

AU - Davenport, Anthony P.

AU - Fabbro, Doriano

AU - Levi-Schaffer, Francesca

AU - Spedding, Michael

AU - Davies, Jamie A.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Given the critical role that the immune system plays in a multitude of diseases, having a clear understanding of the pharmacology of the immune system is crucial to new drug discovery and development. Here we describe the International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb), which connects expert-curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. In the pursuit of new therapeutics, pharmacological databases are a vital resource to researchers through providing accurate information on the fundamental science underlying drug action. This extension to the existing IUPHAR/British Pharmacological Society Guide to Pharmacology supports research into the development of drugs targeted at modulating immune, inflammatory or infectious components of disease. To provide a deeper context for how the resource can support research we show data in GtoImmuPdb relating to a case study on the targeting of vascular inflammation.

AB - Given the critical role that the immune system plays in a multitude of diseases, having a clear understanding of the pharmacology of the immune system is crucial to new drug discovery and development. Here we describe the International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb), which connects expert-curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. In the pursuit of new therapeutics, pharmacological databases are a vital resource to researchers through providing accurate information on the fundamental science underlying drug action. This extension to the existing IUPHAR/British Pharmacological Society Guide to Pharmacology supports research into the development of drugs targeted at modulating immune, inflammatory or infectious components of disease. To provide a deeper context for how the resource can support research we show data in GtoImmuPdb relating to a case study on the targeting of vascular inflammation.

KW - database

KW - immune-therapeutics

KW - immunopharmacology

KW - pharmacology

UR - http://www.scopus.com/inward/record.url?scp=85080974545&partnerID=8YFLogxK

U2 - 10.1111/imm.13175

DO - 10.1111/imm.13175

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 32020584

AN - SCOPUS:85080974545

SN - 0019-2805

VL - 160

SP - 10

EP - 23

JO - Immunology

JF - Immunology

IS - 1

ER -

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this