The LAT story: a tale of cooperativity, coordination, and choreography.

Lakshmi Balagopalan*, Nathan P. Coussens, Eilon Sherman, Lawrence E. Samelson, Connie L. Sommers

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

141 Scopus citations

Abstract

The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. This review discusses interactions of signaling molecules that bind directly or indirectly to LAT and the role of cooperativity in stabilizing LAT-nucleated signaling complexes. In addition, it focuses on how imaging studies visualize signaling assemblies as signaling clusters and demonstrate their dynamic nature and cellular fate. Finally, this review explores the function of LAT based on the interpretation of mouse models using various LAT mutants.

Original languageAmerican English
Pages (from-to)a005512
JournalCold Spring Harbor perspectives in biology
Volume2
Issue number8
DOIs
StatePublished - 1 Aug 2010

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