TY - JOUR
T1 - The LAT story
T2 - a tale of cooperativity, coordination, and choreography.
AU - Balagopalan, Lakshmi
AU - Coussens, Nathan P.
AU - Sherman, Eilon
AU - Samelson, Lawrence E.
AU - Sommers, Connie L.
PY - 2010/8/1
Y1 - 2010/8/1
N2 - The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. This review discusses interactions of signaling molecules that bind directly or indirectly to LAT and the role of cooperativity in stabilizing LAT-nucleated signaling complexes. In addition, it focuses on how imaging studies visualize signaling assemblies as signaling clusters and demonstrate their dynamic nature and cellular fate. Finally, this review explores the function of LAT based on the interpretation of mouse models using various LAT mutants.
AB - The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. This review discusses interactions of signaling molecules that bind directly or indirectly to LAT and the role of cooperativity in stabilizing LAT-nucleated signaling complexes. In addition, it focuses on how imaging studies visualize signaling assemblies as signaling clusters and demonstrate their dynamic nature and cellular fate. Finally, this review explores the function of LAT based on the interpretation of mouse models using various LAT mutants.
UR - http://www.scopus.com/inward/record.url?scp=78349254619&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a005512
DO - 10.1101/cshperspect.a005512
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C2 - 20610546
AN - SCOPUS:78349254619
SN - 1943-0264
VL - 2
SP - a005512
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
IS - 8
ER -