The likelihood of developing a carbapenem-resistant Enterobacteriaceae infection during a hospital stay

Pranita D. Tamma; Abida Kazmi; Yehudit Bergman; Katherine E. Goodman; Ernest Ekunseitan; Joe Amoah; Patricia J. Simner

doi:10.1128/AAC.00757-19

The likelihood of developing a carbapenem-resistant Enterobacteriaceae infection during a hospital stay

Pranita D. Tamma^*, Abida Kazmi, Yehudit Bergman, Katherine E. Goodman, Ernest Ekunseitan, Joe Amoah, Patricia J. Simner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Of 1,455 unique patients in U.S. intensive care units (ICUs), 4% were rectally colonized with CRE on admission. A total of 297 patients were initially negative for carbapenem-resistant Enterobacteriaceae (CRE) and remained in the ICU long enough to contribute additional swabs; 22% of these patients had a subsequent CRE-positive swab, with a median time to CRE colonization of 13 days (interquartile range, 7 to 21 days). Patients colonized with carbapenemase-producing CRE were more likely than those colonized with non-carbapenemase-producing CRE to develop CRE infections during their hospitalizations (36% versus 3%; P 0.05).

Original language	English
Article number	e00757-19
Journal	Antimicrobial Agents and Chemotherapy
Volume	63
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00757-19
State	Published - 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Keywords

CRE
Carbapenem resistance
ICU
Multidrug-resistant organisms

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10.1128/AAC.00757-19

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abstract = "Of 1,455 unique patients in U.S. intensive care units (ICUs), 4% were rectally colonized with CRE on admission. A total of 297 patients were initially negative for carbapenem-resistant Enterobacteriaceae (CRE) and remained in the ICU long enough to contribute additional swabs; 22% of these patients had a subsequent CRE-positive swab, with a median time to CRE colonization of 13 days (interquartile range, 7 to 21 days). Patients colonized with carbapenemase-producing CRE were more likely than those colonized with non-carbapenemase-producing CRE to develop CRE infections during their hospitalizations (36% versus 3%; P 0.05).",

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AU - Kazmi, Abida

AU - Bergman, Yehudit

AU - Goodman, Katherine E.

AU - Ekunseitan, Ernest

AU - Amoah, Joe

AU - Simner, Patricia J.

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The likelihood of developing a carbapenem-resistant Enterobacteriaceae infection during a hospital stay

Abstract

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Keywords

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