The likelihood of developing a carbapenem-resistant Enterobacteriaceae infection during a hospital stay

Pranita D. Tamma*, Abida Kazmi, Yehudit Bergman, Katherine E. Goodman, Ernest Ekunseitan, Joe Amoah, Patricia J. Simner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Of 1,455 unique patients in U.S. intensive care units (ICUs), 4% were rectally colonized with CRE on admission. A total of 297 patients were initially negative for carbapenem-resistant Enterobacteriaceae (CRE) and remained in the ICU long enough to contribute additional swabs; 22% of these patients had a subsequent CRE-positive swab, with a median time to CRE colonization of 13 days (interquartile range, 7 to 21 days). Patients colonized with carbapenemase-producing CRE were more likely than those colonized with non-carbapenemase-producing CRE to develop CRE infections during their hospitalizations (36% versus 3%; P 0.05).

Original languageAmerican English
Article numbere00757-19
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number8
DOIs
StatePublished - 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Keywords

  • CRE
  • Carbapenem resistance
  • ICU
  • Multidrug-resistant organisms

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