The logical structure and validity of experimental designs in pharmacokinetics and clinical pharmacology

Emanuel J. Mason*, Meir Bialer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Much of the literature on research design in clinical pharmacology and pharmacokinetics emphasizes statistical concerns, thus suggesting that a primary ingredient of a valid research design is an appropriate plan for statistical analysis of data. However, statistical validity is only one of several ways to evaluate an experimental study. The present paper reviews the underlying logic and sources of invalidity of experimental drug research suggesting influences and factors which may deceive or lure an experimenter into erroneous conclusions.

Original languageEnglish
Pages (from-to)331-351
Number of pages21
JournalBiopharmaceutics and Drug Disposition
Volume10
Issue number4
DOIs
StatePublished - 1989

Keywords

  • Experimental design
  • Experimental validity
  • Research design

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