The mechanism of action of platinum anticancer agents - What do we really know about it?

Dan Gibson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

Although 40 years have passed since the discovery of the anticancer activity of cisplatin, the mechanism of action of the drug is unclear. There are several working hypotheses that guide the researchers in this field. Unexpected results that we obtained cannot be reconciled with some of those assumptions. Our main intention is to call upon researchers in the field to re-examine the working hypotheses that may have been formulated on the basis of outdated methodologies.

Original languageEnglish
Pages (from-to)10681-10689
Number of pages9
JournalDalton Transactions
Issue number48
DOIs
StatePublished - 2009

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