The mechanism of proton transfer between adjacent sites exposed to water

Aviv Mezer, Ran Friedman, Orly Noivirt, Esther Nachliel, Menachem Gutman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The mechanism of proton transfer between sites that are only a few angstroms apart, using as a model the proton exchange between sites on a small molecule, fluorescein, having two, spectrally distinguishable, proton-binding sites, was investigated. The dynamics of the proton transfer between the two proton-binding sites of the fluorescein indicated that the efficiency of the sites-to-site proton transfer is very sensitive to the presence of the screening electrolyte and has a very high kinetic isotope effect. The state of protonation at each site was constructed. The proton transfer between nearby sites, which were located on a rigid scaffolding, eploys a pathway that utilizes the ordered water in the first solvation layer as carrier.

Original languageAmerican English
Pages (from-to)11379-11388
Number of pages10
JournalJournal of Physical Chemistry B
Issue number22
StatePublished - 9 Jun 2005
Externally publishedYes


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