The methylation state of the proviruses in avian sarcoma virus transformed chick and rat cells

Nitzan Roguel; Henia Moskowitz; Hanna Relevy; Judith Hamburger; Moshe Kotler

doi:10.1016/0167-4781(87)90063-7

The methylation state of the proviruses in avian sarcoma virus transformed chick and rat cells

Nitzan Roguel
, Henia Moskowitz
, Hanna Relevy
, Judith Hamburger
, Moshe Kotler^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The endogenous viruses in the avian cells are not completely methylated, nor are the Schmidt-Ruppin RSV-D (SRD) proviruses in the infected cells completely unmethylated. Avian sarcoma proviruses integrated in rat transformed cloned cells are heavily methylated. In these cells, a region in the 3′ end of the env gene is unmethylated in all the src-containing proviruses but not in the transformed defective (td) proviruses. A possible role for the hypomethylation of the 3′ end of the env region is proposed.

Original language	English
Pages (from-to)	116-122
Number of pages	7
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	910
Issue number	2
DOIs	https://doi.org/10.1016/0167-4781(87)90063-7
State	Published - 20 Nov 1987

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

(Chicken cell)
(Rat cell)
Avian sarcoma virus
Methylation
Provirus
Transformation

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10.1016/0167-4781(87)90063-7

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title = "The methylation state of the proviruses in avian sarcoma virus transformed chick and rat cells",

abstract = "The endogenous viruses in the avian cells are not completely methylated, nor are the Schmidt-Ruppin RSV-D (SRD) proviruses in the infected cells completely unmethylated. Avian sarcoma proviruses integrated in rat transformed cloned cells are heavily methylated. In these cells, a region in the 3′ end of the env gene is unmethylated in all the src-containing proviruses but not in the transformed defective (td) proviruses. A possible role for the hypomethylation of the 3′ end of the env region is proposed.",

keywords = "(Chicken cell), (Rat cell), Avian sarcoma virus, Methylation, Provirus, Transformation",

author = "Nitzan Roguel and Henia Moskowitz and Hanna Relevy and Judith Hamburger and Moshe Kotler",

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T1 - The methylation state of the proviruses in avian sarcoma virus transformed chick and rat cells

AU - Roguel, Nitzan

AU - Moskowitz, Henia

AU - Relevy, Hanna

AU - Hamburger, Judith

AU - Kotler, Moshe

PY - 1987/11/20

Y1 - 1987/11/20

N2 - The endogenous viruses in the avian cells are not completely methylated, nor are the Schmidt-Ruppin RSV-D (SRD) proviruses in the infected cells completely unmethylated. Avian sarcoma proviruses integrated in rat transformed cloned cells are heavily methylated. In these cells, a region in the 3′ end of the env gene is unmethylated in all the src-containing proviruses but not in the transformed defective (td) proviruses. A possible role for the hypomethylation of the 3′ end of the env region is proposed.

AB - The endogenous viruses in the avian cells are not completely methylated, nor are the Schmidt-Ruppin RSV-D (SRD) proviruses in the infected cells completely unmethylated. Avian sarcoma proviruses integrated in rat transformed cloned cells are heavily methylated. In these cells, a region in the 3′ end of the env gene is unmethylated in all the src-containing proviruses but not in the transformed defective (td) proviruses. A possible role for the hypomethylation of the 3′ end of the env region is proposed.

KW - (Chicken cell)

KW - (Rat cell)

KW - Avian sarcoma virus

KW - Methylation

KW - Provirus

KW - Transformation

UR - https://www.scopus.com/pages/publications/0023661220

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JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

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ER -

The methylation state of the proviruses in avian sarcoma virus transformed chick and rat cells

Abstract

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Keywords

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