The Microbiology Characteristics of Infected Branchial Cleft Anomalies

Nir Hirshoren*, Neta Fried, Jeffrey M. Weinberger, Ron Eliashar, Maya Korem

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objectives: To investigate the microbiology profile of infected branchial cleft anomalies compared to deep neck infection and explore the influence of age on culture findings. Study Design: A retrospective case control study. Setting: A single tertiary medical center. Subjects and Methods: Patients treated for branchial cleft anomalies between 2006 and 2016 were included. Demographic data, disease and treatment parameters, and microbiology profile, including bacteria classification, antibiotics resistance patterns, and number of pathogens, were analyzed. Results: Of 278 cases treated for branchial cleft anomalies, we have analyzed 69 cases with infection and pathogen identification. The proportion of monobacterial infections was higher (70.6% vs 44.3%; P =.003; odds ratio [OR], 3.02) and the proportion of Streptococcus species infection was lower (48.9% vs 77.2%; P =.001; OR, 0.282) among the infected branchial cleft cases compared to deep neck infections. Anaerobic bacteria infection did not differ between groups (17.8% and 16.5%, respectively). There was a nonsignificant tendency toward more resistant bacterial strains among the infected branchial clefts (15.6% vs 6.3%; P =.118; OR, 2.726). There was no difference between the bacterial profile of patients younger or older than 16 years. Conclusions: The microbiology profile of infected branchial cleft anomalies is not age related and is different from that of deep neck infections. We demonstrate a relatively high frequency of monobacterial infections, relatively lower streptococcal infection rates, and a substantial contribution by resistant species and anaerobes. Empiric antibiotic treatment should cover Streptococcus species, including penicillin-resistant species, as well as clindamycin-resistant anaerobes.

Original languageAmerican English
JournalOTO Open
Volume3
Issue number3
DOIs
StatePublished - 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Authors 2019.

Keywords

  • anaerobic bacteria
  • antibiotics resistance
  • branchial cleft anomalies
  • deep neck infection
  • microbiology profile
  • polymicrobial infection
  • streptococcal infection

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