The molecular basis of common and rare fragile sites

Michal Schwartz, Eitan Zlotorynski, Batsheva Kerem*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

Fragile sites are specific loci that form gaps and constrictions on chromosomes exposed to partial replication stress. Fragile sites are classified as rare or common, depending on their induction and frequency within the population. These loci are known to be involved in chromosomal rearrangements in tumors and are associated with human diseases. Therefore, the understanding of the molecular basis of fragile sites is of high significance. Here we discuss the works performed in recent years that investigated the characteristics of fragile sites which underlie their inherent instability.

Original languageAmerican English
Pages (from-to)13-26
Number of pages14
JournalCancer Letters
Volume232
Issue number1
DOIs
StatePublished - 28 Jan 2006

Keywords

  • Common fragile sites
  • Genomic instability
  • Rare fragile sites
  • Replication stress

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