The Mood Cycle Hypothesis: Possible Involvement Of Steroid Hormones In Mood Regulation By Means Of Na+,K+-Atpase Inhibition

Noam Traub, David Lichtstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The mood cycle hypothesis attempts to propose a model for mood regulation based on current data. The hypothesis contends that steroid hormones inhibit sodium-potassium adenosine triphosphatase (Na+, K+-ATPase; Na+pump) in the hypothalamus, either directly or by converting into digitalis-like compounds. This inhibition stimulates β-endorphin (β-E) secretion, which is normally construed as elevated mood. In turn, β-E inhibits steroid secretion, thus completing negative feedback loops. These loops are collectively termed the mood cycle.

Original languageEnglish
Pages (from-to)375-394
Number of pages20
JournalJournal of Basic and Clinical Physiology and Pharmacology
Volume11
Issue number4
DOIs
StatePublished - 2000

Keywords

  • cholesterol
  • digitalis-like compounds
  • mood
  • Napump
  • steroid hormones
  • β-endorphin

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