TY - JOUR
T1 - The Mood Cycle Hypothesis
T2 - Possible Involvement Of Steroid Hormones In Mood Regulation By Means Of Na+,K+-Atpase Inhibition
AU - Traub, Noam
AU - Lichtstein, David
PY - 2000
Y1 - 2000
N2 - The mood cycle hypothesis attempts to propose a model for mood regulation based on current data. The hypothesis contends that steroid hormones inhibit sodium-potassium adenosine triphosphatase (Na+, K+-ATPase; Na+pump) in the hypothalamus, either directly or by converting into digitalis-like compounds. This inhibition stimulates β-endorphin (β-E) secretion, which is normally construed as elevated mood. In turn, β-E inhibits steroid secretion, thus completing negative feedback loops. These loops are collectively termed the mood cycle.
AB - The mood cycle hypothesis attempts to propose a model for mood regulation based on current data. The hypothesis contends that steroid hormones inhibit sodium-potassium adenosine triphosphatase (Na+, K+-ATPase; Na+pump) in the hypothalamus, either directly or by converting into digitalis-like compounds. This inhibition stimulates β-endorphin (β-E) secretion, which is normally construed as elevated mood. In turn, β-E inhibits steroid secretion, thus completing negative feedback loops. These loops are collectively termed the mood cycle.
KW - cholesterol
KW - digitalis-like compounds
KW - mood
KW - Napump
KW - steroid hormones
KW - β-endorphin
UR - http://www.scopus.com/inward/record.url?scp=0034474422&partnerID=8YFLogxK
U2 - 10.1515/JBCPP.2000.11.4.375
DO - 10.1515/JBCPP.2000.11.4.375
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C2 - 11248948
AN - SCOPUS:0034474422
SN - 0792-6855
VL - 11
SP - 375
EP - 394
JO - Journal of Basic and Clinical Physiology and Pharmacology
JF - Journal of Basic and Clinical Physiology and Pharmacology
IS - 4
ER -