The mood response and plasma cyclic-AMP response to intravenous methylphenidate

R. Kadouch; R. H. Belmaker; R. P. Ebstein; L. Peres

doi:10.1159/000117610

The mood response and plasma cyclic-AMP response to intravenous methylphenidate

R. Kadouch
, R. H. Belmaker
, R. P. Ebstein
, L. Peres

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Plasma cyclic-AMP responses to adrenergic agonists are due to stimulation of the peripheral β-adrenergic receptor. Mood responses to stimulants are thought to be due to actions leading to stimulation of central catecholamine receptors. To determine if a peripheral measure of receptor sensitivity could predict central mood effects of stimulants, the plasma cyclic-AMP response and the mood response to intravenous methylphenidate were determined simultaneously in 13 subjects. No correlation between the two responses was found.

Original language	English
Pages (from-to)	250-255
Number of pages	6
Journal	Neuropsychobiology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1159/000117610
State	Published - 1977
Externally published	Yes

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AB - Plasma cyclic-AMP responses to adrenergic agonists are due to stimulation of the peripheral β-adrenergic receptor. Mood responses to stimulants are thought to be due to actions leading to stimulation of central catecholamine receptors. To determine if a peripheral measure of receptor sensitivity could predict central mood effects of stimulants, the plasma cyclic-AMP response and the mood response to intravenous methylphenidate were determined simultaneously in 13 subjects. No correlation between the two responses was found.

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The mood response and plasma cyclic-AMP response to intravenous methylphenidate

Abstract

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