The Morpho/Functional Discrepancy in the Cerebellar Cortex: Looks Alone are Deceptive

Dan Rokni*, Rodolfo Llinas, Yosef Yarom

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

In a recent report we demonstrated that stimulation of cerebellar mossy fibers synchronously activates Purkinje cells that are located directly above the site of stimulation. We found that the activated Purkinje cells are arranged in a radial patch on the cerebellar surface and that this organization is independent of the integrity of the inhibitory system. This arrangement of activity is counterintuitive. The anatomical structure with the extensive parallel fiber system implies that mossy fiber stimulation will activate Purkinje cells along a beam of parallel fibers. In this short review we highlight this discrepancy between anatomical structure and functional dynamics and suggest a plausible underlying mechanism.

Original languageAmerican English
Pages (from-to)192-198
Number of pages7
JournalFrontiers in Neuroscience
Volume2
Issue number2
DOIs
StatePublished - 15 Dec 2008

Bibliographical note

Publisher Copyright:
© Copyright: © 2008 Rokni, Llinas and Yarom.

Keywords

  • Purkinje cell
  • climbing fiber
  • mossy fiber
  • parallel fibers

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