The narrowing olfactory landscape of insect odorant receptors

Jonathan D. Bohbot*, Ronald J. Pitts

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The molecular basis of odorant detection and its corollary, the task of the odorant receptor, are fundamental to understanding olfactory coding and sensory ecology. Based on their molecular receptive range, olfactory receptors have been classified as pheromone and non-pheromone receptors, which are respectively activated by a single pheromone component ("specialist") or by multiple odorant ligands ("generalist"). This functional distinction is unique among ligand-gated ion channels and has shaped how we model olfactory coding both at the peripheral and central levels. Here, we revisit the long-standing combinatorial theory of olfaction and argue, based on physiological, pharmacological, evolutionary, and experimental grounds that the task of the odorant receptor is not different from that of neurotransmitter receptors localized in neuronal synapses.

Original languageAmerican English
Article number39
JournalFrontiers in Ecology and Evolution
Volume3
Issue numberAPR
DOIs
StatePublished - 10 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015 Bohbot and Pitts.

Keywords

  • Ligand-gated ion channel
  • Neurotransmitter receptors
  • Odorant receptor
  • Olfactory communication
  • Synaptic communication

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