The neuronal class 2 TSR proteins F-spondin and Mindin: A small family with divergent biological activities

Yael Feinstein, Avihu Klar*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

51 Scopus citations

Abstract

F-spondin and Mindin are members of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of F-spondin proteins are typical of class 2 TSRs. F-spondin and Mindin are evolutionarily conserved proteins. The embryonic expression of the vertebrate genes is enriched in the nervous system, mainly at the floor plate and the hippocampus. Similar to thrombospondin, F-spondin and Mindin are extracellular matrix attached molecules that promote neurite outgrowth and inhibit angiogenesis. Analysis of gain and loss of function experiments reveal that F-spondin is required for accurate pathfinding of embryonic axons. F-spondin plays a dual role in patterning axonal trajectories: it promotes the outgrowth of commissural and inhibits the outgrowth of motor axons. Macrophages of Mindin-deficient mice exhibit defective responses to a broad spectrum of microbial stimuli. This may implicate Mindin and F-spondin in inflammatory processes in the nervous system.

Original languageAmerican English
Pages (from-to)975-980
Number of pages6
JournalInternational Journal of Biochemistry and Cell Biology
Volume36
Issue number6
DOIs
StatePublished - Jun 2004

Keywords

  • Adhesion
  • Axon guidance
  • Commissural
  • Extracellular matrix
  • Floor plate
  • Motor axons

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