TY - JOUR
T1 - The nuclear lamina and its proposed roles in tumorigenesis
T2 - Projection on the hematologic malignancies and future targeted therapy
AU - Prokocimer, Miron
AU - Margalit, Ayelet
AU - Gruenbaum, Yosef
PY - 2006/8
Y1 - 2006/8
N2 - The nuclear lamina, a network of lamin filaments and lamin-associated proteins, is located between the inner nuclear membrane and the peripheral chromatin. The nuclear lamina is involved in numerous nuclear functions including maintaining nuclear shape, determining nuclear positioning, organizing chromatin and regulating the cell cycle, DNA replication, transcription, cell differentiation, apoptosis, and aging. Alterations in the composition of nuclear lamins and their associated proteins are currently emerging as an additional event involved in malignant transformation, tumor propagation and progression, thus identifying potential novel targets for future anti-cancer therapy. Here, we review the current knowledge on lamin expression patterns in cells of hematologic malignancies and give an overview on the roles of the nuclear lamina proteins in heterochromatin organization, apoptosis, and aging with special emphasis on the relevance in cancer development.
AB - The nuclear lamina, a network of lamin filaments and lamin-associated proteins, is located between the inner nuclear membrane and the peripheral chromatin. The nuclear lamina is involved in numerous nuclear functions including maintaining nuclear shape, determining nuclear positioning, organizing chromatin and regulating the cell cycle, DNA replication, transcription, cell differentiation, apoptosis, and aging. Alterations in the composition of nuclear lamins and their associated proteins are currently emerging as an additional event involved in malignant transformation, tumor propagation and progression, thus identifying potential novel targets for future anti-cancer therapy. Here, we review the current knowledge on lamin expression patterns in cells of hematologic malignancies and give an overview on the roles of the nuclear lamina proteins in heterochromatin organization, apoptosis, and aging with special emphasis on the relevance in cancer development.
KW - Aging
KW - Apoptosis
KW - Cancer
KW - Chromatin
KW - Lamin
KW - Laminopathies
KW - Nuclear envelope
UR - http://www.scopus.com/inward/record.url?scp=33748608275&partnerID=8YFLogxK
U2 - 10.1016/j.jsb.2006.02.016
DO - 10.1016/j.jsb.2006.02.016
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C2 - 16697219
AN - SCOPUS:33748608275
SN - 1047-8477
VL - 155
SP - 351
EP - 360
JO - Journal of Structural Biology
JF - Journal of Structural Biology
IS - 2
ER -