TY - JOUR
T1 - The nuclear lamina comes of age
AU - Gruenbaum, Yosef
AU - Margalit, Ayelet
AU - Goldman, Robert D.
AU - Shumaker, Dale K.
AU - Wilson, Katherine L.
PY - 2005/1
Y1 - 2005/1
N2 - Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins, nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, gene regulation and signal transduction. Some link the nucleoskeleton to cytoskeletal structures, ensuring that the nucleus and centrosome assume appropriate intracellular positions. These complexes provide new insights into cell architecture, as well as a foundation for the understanding of the molecular mechanisms that underlie the human laminopathies - clinical disorders that range from Emery-Dreifuss muscular dystrophy to the accelerated ageing seen in Hutchinson-Gilford progeria syndrome.
AB - Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins, nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, gene regulation and signal transduction. Some link the nucleoskeleton to cytoskeletal structures, ensuring that the nucleus and centrosome assume appropriate intracellular positions. These complexes provide new insights into cell architecture, as well as a foundation for the understanding of the molecular mechanisms that underlie the human laminopathies - clinical disorders that range from Emery-Dreifuss muscular dystrophy to the accelerated ageing seen in Hutchinson-Gilford progeria syndrome.
UR - http://www.scopus.com/inward/record.url?scp=11244320353&partnerID=8YFLogxK
U2 - 10.1038/nrm1550
DO - 10.1038/nrm1550
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C2 - 15688064
AN - SCOPUS:11244320353
SN - 1471-0072
VL - 6
SP - 21
EP - 31
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 1
ER -