The occurrence of extracellular matrix vesicles in pulmonary alveolar microlithiasis

I. Bab, E. Rosenmann, Z. Ne'eman, J. Sela*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Mineralization in pulmonary alveolar microlithiasis was studied by transmission electron microscopy. The disease is characterized by psammoma like calcifications composed of hydroxyapatite crystals. The calcifications were surrounded by typical forming cells and matrix composed of collagen fibers arranged in a longitudinal pattern. Abundant calcifying extracellular matrix vesicles were found between the cells and the calcified fronts. The type of calcification found in the present lesion is similar to ectopic primary mineralization in other diseases, embryonal ossification and bone wound healing.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalVirchows Archiv A Pathological Anatomy and Histology
Volume391
Issue number3
DOIs
StatePublished - Jan 1981

Keywords

  • Matrix vesicles
  • Pulmonary alveolar microlithiasis
  • TEM

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