TY - JOUR
T1 - The outcome of pregnancy following topiramate treatment
T2 - A study on 52 pregnancies
AU - Ornoy, Asher
AU - Zvi, Naama
AU - Arnon, Judy
AU - Wajnberg, Rebecka
AU - Shechtman, Svetlana
AU - Diav-Citrin, Orna
PY - 2008/4
Y1 - 2008/4
N2 - In spite of a substantial increase in the use of topiramate at child bearing age, very little is known regarding its use in pregnancy. We describe the outcome of 52 pregnancies with 41 liveborn infants from which it seems that topiramate reduces birth weight without decreasing gestational age at delivery, but does not seem to increase the risk for structural defects. There was an increased rate of spontaneous abortions not related to the drug effects.
AB - In spite of a substantial increase in the use of topiramate at child bearing age, very little is known regarding its use in pregnancy. We describe the outcome of 52 pregnancies with 41 liveborn infants from which it seems that topiramate reduces birth weight without decreasing gestational age at delivery, but does not seem to increase the risk for structural defects. There was an increased rate of spontaneous abortions not related to the drug effects.
KW - Congenital anomalies
KW - Pregnancy
KW - Spontaneous abortions
KW - Topiramate
UR - http://www.scopus.com/inward/record.url?scp=44149124250&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2008.03.001
DO - 10.1016/j.reprotox.2008.03.001
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C2 - 18424066
AN - SCOPUS:44149124250
SN - 0890-6238
VL - 25
SP - 388
EP - 389
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 3
ER -