TY - JOUR
T1 - The ovarian endothelin network
T2 - an evolving story
AU - Meidan, Rina
AU - Levy, Nitzan
PY - 2007/12
Y1 - 2007/12
N2 - The endothelin (ET) system consists of three ET isopeptides, several converting enzyme isoforms and two G-protein-coupled receptors, ETA and ETB, which are linked to multiple signaling pathways. Less than 20 years after the initial detection of ET-1 in granulosa cells, the ovarian ET network continues to expand with the discovery of new members and functions. ETs influence a broad range of essential reproductive processes, such as ovulation, steroidogenesis and luteolysis. Therefore, a more comprehensive understanding of the ovarian ET network might provide new strategies for controlling reproduction. This review presents up-to-date findings on the ET network in the ovary.
AB - The endothelin (ET) system consists of three ET isopeptides, several converting enzyme isoforms and two G-protein-coupled receptors, ETA and ETB, which are linked to multiple signaling pathways. Less than 20 years after the initial detection of ET-1 in granulosa cells, the ovarian ET network continues to expand with the discovery of new members and functions. ETs influence a broad range of essential reproductive processes, such as ovulation, steroidogenesis and luteolysis. Therefore, a more comprehensive understanding of the ovarian ET network might provide new strategies for controlling reproduction. This review presents up-to-date findings on the ET network in the ovary.
UR - http://www.scopus.com/inward/record.url?scp=36249026290&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2007.09.002
DO - 10.1016/j.tem.2007.09.002
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C2 - 17997104
AN - SCOPUS:36249026290
SN - 1043-2760
VL - 18
SP - 379
EP - 385
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 10
ER -