The ovarian endothelin network: an evolving story

Rina Meidan; Nitzan Levy

doi:10.1016/j.tem.2007.09.002

The ovarian endothelin network: an evolving story

Rina Meidan^*
, Nitzan Levy

^*Corresponding author for this work

Department of Animal Sciences

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

The endothelin (ET) system consists of three ET isopeptides, several converting enzyme isoforms and two G-protein-coupled receptors, ETA and ETB, which are linked to multiple signaling pathways. Less than 20 years after the initial detection of ET-1 in granulosa cells, the ovarian ET network continues to expand with the discovery of new members and functions. ETs influence a broad range of essential reproductive processes, such as ovulation, steroidogenesis and luteolysis. Therefore, a more comprehensive understanding of the ovarian ET network might provide new strategies for controlling reproduction. This review presents up-to-date findings on the ET network in the ovary.

Original language	English
Pages (from-to)	379-385
Number of pages	7
Journal	Trends in Endocrinology and Metabolism
Volume	18
Issue number	10
DOIs	https://doi.org/10.1016/j.tem.2007.09.002
State	Published - Dec 2007

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10.1016/j.tem.2007.09.002

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abstract = "The endothelin (ET) system consists of three ET isopeptides, several converting enzyme isoforms and two G-protein-coupled receptors, ETA and ETB, which are linked to multiple signaling pathways. Less than 20 years after the initial detection of ET-1 in granulosa cells, the ovarian ET network continues to expand with the discovery of new members and functions. ETs influence a broad range of essential reproductive processes, such as ovulation, steroidogenesis and luteolysis. Therefore, a more comprehensive understanding of the ovarian ET network might provide new strategies for controlling reproduction. This review presents up-to-date findings on the ET network in the ovary.",

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AB - The endothelin (ET) system consists of three ET isopeptides, several converting enzyme isoforms and two G-protein-coupled receptors, ETA and ETB, which are linked to multiple signaling pathways. Less than 20 years after the initial detection of ET-1 in granulosa cells, the ovarian ET network continues to expand with the discovery of new members and functions. ETs influence a broad range of essential reproductive processes, such as ovulation, steroidogenesis and luteolysis. Therefore, a more comprehensive understanding of the ovarian ET network might provide new strategies for controlling reproduction. This review presents up-to-date findings on the ET network in the ovary.

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The ovarian endothelin network: an evolving story

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