The pharmacokinetics and interactions of new antiepileptic drugs: An overview

Meir Bialer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

In the past decade 10 new antiepileptic drugs (AEDs) have been introduced: felbamate, gabapentin, lamotrigine, levetiracetem, oxcarbazepine, pregabalin, tiagabine, topiramate, vigabatrin, and zonisamide. The pharmacokinetics (PK) of these new AEDs as well as their potential for drug interactions are reviewed in this article. In general, new AEDs have better PK profies and are less involved in drug interactions than the 4 established AEDs: phenobarbital, phenytoin, carbamazepine, and valproic acid. However, in spite of the large therapeutic arsenal of old and new AEDs, about 30% of epileptic patients are still not seizure-free, and thus, there is a substantial need to develop new AEDs.

Original languageEnglish
Pages (from-to)722-726
Number of pages5
JournalTherapeutic Drug Monitoring
Volume27
Issue number6
DOIs
StatePublished - Dec 2005

Keywords

  • Antiepileptic drugs
  • Interactions
  • Pharmacokinetics

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