Carbon dioxide (CO2) is an end product of cellular respiration, a process by which organisms including all plants, animals, many fungi and some bacteria obtain energy.1 CO2 has several physiologic roles in respiration, pH buffering, autoregulation of the blood supply and others.2 Here we review recent findings from studies in mammalian lung cells, Caenorhabditis elegans and Drosophila melanogaster that help shed light on the molecular sensing and response to hypercapnia.
Bibliographical noteFunding Information:
This work was supported by NIH grant HL085534 (Y.G.), Hedson fund for medical research Science, Manlam Office, Technion, The Israel Institute of Technology and The Rappaport Family Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel (Z.S.A.).
- Caenorhabditis elegans
- Drosophila melanogaster
- Innate immunity
- Lung diseases