The Placental Barrier: the Gate and the Fate in Drug Distribution

Nino Tetro, Sonia Moushaev, Miriam Rubinchik-Stern, Sara Eyal*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations

Abstract

Optimal development of the embryo and the fetus depends on placental passage of gases, nutrients, hormones, and waste products. These molecules are transferred across the placenta via passive diffusion, carrier-mediated cellular uptake and efflux, and transcytosis pathways. The same mechanisms additionally control the rate and extent of transplacental transfer of drugs taken by the pregnant mother. Essentially all drugs cross the placenta to a certain extent, and some accumulate in the placenta itself at levels that can even exceed those in maternal plasma. Hence, even drugs that are not efficiently transferred across the placenta may indirectly affect fetal development by interfering with placental function. In this article, we describe key properties of the placental barrier and their modulation by medications. We highlight implications for pharmacotherapy and novel approaches for drug delivery in pregnant women and their fetuses.

Original languageAmerican English
Article number71
JournalPharmaceutical Research
Volume35
Issue number4
DOIs
StatePublished - 1 Apr 2018

Bibliographical note

Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • drug transporters
  • maternal-fetal pharmacology
  • placenta
  • placental transfer
  • pregnancy

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