TY - JOUR
T1 - The potential of lipid emulsion for ocular delivery of lipophilic drugs
AU - Tamilvanan, Shunmugaperumal
AU - Benita, Simon
PY - 2004/9
Y1 - 2004/9
N2 - For nearly a decade, oil-in-water lipid emulsions containing either anionic or cationic droplets have been recognized as an interesting and promising ocular topical delivery vehicle for lipophilic drugs. The aim of this review is to present the potential of lipid emulsions for ocular delivery of lipophilic drugs. The review covers an update on the state of the art of incorporating the lipophilic drugs, a brief description concerning the components and the classification of lipid emulsions. The ocular fate following topical instillation, safety evaluation experiments and the applications of lipid emulsions are thoroughly discussed.
AB - For nearly a decade, oil-in-water lipid emulsions containing either anionic or cationic droplets have been recognized as an interesting and promising ocular topical delivery vehicle for lipophilic drugs. The aim of this review is to present the potential of lipid emulsions for ocular delivery of lipophilic drugs. The review covers an update on the state of the art of incorporating the lipophilic drugs, a brief description concerning the components and the classification of lipid emulsions. The ocular fate following topical instillation, safety evaluation experiments and the applications of lipid emulsions are thoroughly discussed.
KW - Anionic
KW - Cationic
KW - Emulsion
KW - Ocular bioavailability
KW - Review
KW - Safety
UR - http://www.scopus.com/inward/record.url?scp=3843096094&partnerID=8YFLogxK
U2 - 10.1016/j.ejpb.2004.03.033
DO - 10.1016/j.ejpb.2004.03.033
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C2 - 15296961
AN - SCOPUS:3843096094
SN - 0939-6411
VL - 58
SP - 357
EP - 368
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
IS - 2
ER -