TY - JOUR
T1 - The prodrome of autism
T2 - Early behavioral and biological signs, regression, peri- and post-natal development and genetics
AU - Yirmiya, Nurit
AU - Charman, Tony
PY - 2010/4
Y1 - 2010/4
N2 - Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the 'core' disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and 'high risk' sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. While no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate early presentation and even 'prevent' emergence of the full syndrome.
AB - Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the 'core' disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and 'high risk' sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. While no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate early presentation and even 'prevent' emergence of the full syndrome.
KW - Autism spectrum disorders
KW - Brain development
KW - Diagnosis
KW - Early markers
KW - Genetics
KW - Perinatal development
KW - Siblings
UR - http://www.scopus.com/inward/record.url?scp=77949398833&partnerID=8YFLogxK
U2 - 10.1111/j.1469-7610.2010.02214.x
DO - 10.1111/j.1469-7610.2010.02214.x
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C2 - 20085609
AN - SCOPUS:77949398833
SN - 0021-9630
VL - 51
SP - 432
EP - 458
JO - Journal of Child Psychology and Psychiatry and Allied Disciplines
JF - Journal of Child Psychology and Psychiatry and Allied Disciplines
IS - 4
ER -