The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine.
Bibliographical noteFunding Information:
This work was supported in part by the Lee Kong Chian School of Medicine, Nanyang Technological University (Singapore), Start-Up Grant (K.P.) and the National Research Foundation (Singapore) under its Investigatorship Program (grant NRF-NRFI06-2020-0004). R.S. is supported by a scholarship from the NTU Institute for Health Technologies, Interdisciplinary Graduate Program, Nanyang Technological University. We thank Sung Jae Shin for the gift of the clinical isolates.
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- Cytochrome bcc:aa
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- Terminal oxidase