The QcrB inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus

Ria Sorayah; Garret C. Moraski; Daniel Barkan; Kevin Pethe

doi:10.1128/AAC.00964-21

The QcrB inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus

Ria Sorayah, Garret C. Moraski, Daniel Barkan, Kevin Pethe^*

^*Corresponding author for this work

The Koret School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine.

Original language	English
Article number	e00964-21
Journal	Antimicrobial Agents and Chemotherapy
Volume	65
Issue number	12
DOIs	https://doi.org/10.1128/AAC.00964-21
State	Published - Dec 2021

Bibliographical note

Publisher Copyright:
Copyright © 2021 American Society for Microbiology. All Rights Reserved.

Keywords

Cytochrome bcc:aa
Nontuberculous mycobacteria
Oxidative phosphorylation
Q203
Terminal oxidase
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00964-21

Cite this

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abstract = "The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine.",

keywords = "Cytochrome bcc:aa, Nontuberculous mycobacteria, Oxidative phosphorylation, Q203, Terminal oxidase, Tuberculosis",

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AU - Pethe, Kevin

PY - 2021/12

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AB - The antituberculosis drug telacebec is ineffective against Mycobacterium abscessus. A recent study suggested that TB47, a telacebec analogue, potentiated the efficacy of clofazimine against M. abscessus. Here, we report that TB47 not only is ineffective against M. abscessus in vitro but also does not potentiate the activity of clofazimine.

KW - Cytochrome bcc:aa

KW - Nontuberculous mycobacteria

KW - Oxidative phosphorylation

KW - Q203

KW - Terminal oxidase

KW - Tuberculosis

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ER -

The QcrB inhibitors TB47 and telacebec do not potentiate the activity of clofazimine in mycobacterium abscessus

Abstract

Bibliographical note

Keywords

UN SDGs

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