The Question of the End Effector of Ischemic Postconditioning of the Heart

L. N. Maslov; N. V. Naryzhnaya; L. Hanush; Jian-Ming Pei; A. N. Baikov; I. Zhang; H. Wang; I. G. Khaliulin

doi:10.1007/s11055-015-0069-9

The Question of the End Effector of Ischemic Postconditioning of the Heart

L. N. Maslov, N. V. Naryzhnaya, L. Hanush, Jian-Ming Pei, A. N. Baikov, I. Zhang, H. Wang, I. G. Khaliulin

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Analysis of published data provided evidence that the main candidates for the role of the end effector for ischemic postconditioning of the heart are: 1) BK-type K+ channels (big conductance K+ channels); 2) mitochondrial ATP-sensitive K+ channels; and 3) MPT pores (mitochondrial permeability transition pores). However, some investigators believe that mitoKATP channels constitute no more than an intermediate link in the chain of signal events mediating increases in the tolerance of the heart to the actions of ischemia-reperfusion. Of these three structures, MPT pores are the most likely end effector. However, it remains possible that there is no unique molecular complex which is the sole end effector of postconditioning. It may be that there are several effectors mediating the cardioprotective effects of the adaptive postconditioning phenomenon.

Original language	American English
Pages (from-to)	283-294
Number of pages	12
Journal	Neuroscience and Behavioral Physiology
Volume	45
Issue number	3
DOIs	https://doi.org/10.1007/s11055-015-0069-9
State	Published - 2015

Bibliographical note

Publisher Copyright:
© 2015, Springer Science+Business Media New York.

Keywords

BK channel
K channel
MPT pore
end effector
heart
postconditioning

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11055-015-0069-9

Cite this

@article{5c46f19f22d44d769dbb07418a87622e,

title = "The Question of the End Effector of Ischemic Postconditioning of the Heart",

abstract = "Analysis of published data provided evidence that the main candidates for the role of the end effector for ischemic postconditioning of the heart are: 1) BK-type K+ channels (big conductance K+ channels); 2) mitochondrial ATP-sensitive K+ channels; and 3) MPT pores (mitochondrial permeability transition pores). However, some investigators believe that mitoKATP channels constitute no more than an intermediate link in the chain of signal events mediating increases in the tolerance of the heart to the actions of ischemia-reperfusion. Of these three structures, MPT pores are the most likely end effector. However, it remains possible that there is no unique molecular complex which is the sole end effector of postconditioning. It may be that there are several effectors mediating the cardioprotective effects of the adaptive postconditioning phenomenon.",

keywords = "BK channel, K channel, MPT pore, end effector, heart, postconditioning",

author = "Maslov, {L. N.} and Naryzhnaya, {N. V.} and L. Hanush and Jian-Ming Pei and Baikov, {A. N.} and I. Zhang and H. Wang and Khaliulin, {I. G.}",

note = "Publisher Copyright: {\textcopyright} 2015, Springer Science+Business Media New York.",

year = "2015",

doi = "10.1007/s11055-015-0069-9",

language = "American English",

volume = "45",

pages = "283--294",

journal = "Neuroscience and Behavioral Physiology",

issn = "1573-899X",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - The Question of the End Effector of Ischemic Postconditioning of the Heart

AU - Maslov, L. N.

AU - Naryzhnaya, N. V.

AU - Hanush, L.

AU - Pei, Jian-Ming

AU - Baikov, A. N.

AU - Zhang, I.

AU - Wang, H.

AU - Khaliulin, I. G.

PY - 2015

Y1 - 2015

N2 - Analysis of published data provided evidence that the main candidates for the role of the end effector for ischemic postconditioning of the heart are: 1) BK-type K+ channels (big conductance K+ channels); 2) mitochondrial ATP-sensitive K+ channels; and 3) MPT pores (mitochondrial permeability transition pores). However, some investigators believe that mitoKATP channels constitute no more than an intermediate link in the chain of signal events mediating increases in the tolerance of the heart to the actions of ischemia-reperfusion. Of these three structures, MPT pores are the most likely end effector. However, it remains possible that there is no unique molecular complex which is the sole end effector of postconditioning. It may be that there are several effectors mediating the cardioprotective effects of the adaptive postconditioning phenomenon.

AB - Analysis of published data provided evidence that the main candidates for the role of the end effector for ischemic postconditioning of the heart are: 1) BK-type K+ channels (big conductance K+ channels); 2) mitochondrial ATP-sensitive K+ channels; and 3) MPT pores (mitochondrial permeability transition pores). However, some investigators believe that mitoKATP channels constitute no more than an intermediate link in the chain of signal events mediating increases in the tolerance of the heart to the actions of ischemia-reperfusion. Of these three structures, MPT pores are the most likely end effector. However, it remains possible that there is no unique molecular complex which is the sole end effector of postconditioning. It may be that there are several effectors mediating the cardioprotective effects of the adaptive postconditioning phenomenon.

KW - BK channel

KW - K channel

KW - MPT pore

KW - end effector

KW - heart

KW - postconditioning

UR - http://www.scopus.com/inward/record.url?scp=84957436380&partnerID=8YFLogxK

U2 - 10.1007/s11055-015-0069-9

DO - 10.1007/s11055-015-0069-9

M3 - Article

SN - 1573-899X

VL - 45

SP - 283

EP - 294

JO - Neuroscience and Behavioral Physiology

JF - Neuroscience and Behavioral Physiology

IS - 3

ER -

The Question of the End Effector of Ischemic Postconditioning of the Heart

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this