The rate of fusion of phospholipid vesicles and the role of bilayer curvature

Shlomo Nir*, Jan Wilschut, Joe Bentz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Kinetics of Ca2+-induced fusion of phosphatidylserine vesicles is studiied for lipid concentrations varying from 1 μM to 100 μM. Fusion is monitored by mixing of aqueous vesicle contents and by explicitly accounting for leakage. The analysis provides separately rates of aggregation and fusion. The rate of fusion per se decreases steeply with vesicle size.

Original languageEnglish
Pages (from-to)275-278
Number of pages4
JournalBiochimica et Biophysica Acta - Biomembranes
Volume688
Issue number1
DOIs
StatePublished - 28 May 1982

Keywords

  • Bilayer curvature
  • Fusion rate
  • Phospholipid

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