Abstract
Spleen cells from rats infected with Plasmodium berghei were stimulated in vitro by phytohemagglutinin, concanavalin A and by bacterial lipopolysaccharide. In addition the release of lymphocyte activating factor (LAF) by splenic macrophages was assayed using a heterologous thymocyte culture. The reactivity of spleen lymphocytes from malarious rats was severely affected. The cells did not react either to the T cell specific mitogens or to the B cell stimulant. The reactivity of macrophages, as measured by the release of LAF, was not altered by the disease.
Original language | English |
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Pages (from-to) | 139-145 |
Number of pages | 7 |
Journal | Clinical and Experimental Immunology |
Volume | 24 |
Issue number | 1 |
State | Published - 1976 |