TY - JOUR
T1 - The red blood cell in vascular occlusion
AU - Yedgar, Saul
AU - Koshkaryev, Alexander
AU - Barshtein, Gregory
PY - 2002
Y1 - 2002
N2 - Red blood cells (RBC) have unique flow-affecting properties - namely, aggregability, deformability and adherence to endothelial cells (EC) - which play major roles in blood flow. Under normal flow-induced shear stress RBC are dispersed, their adherence to EC is insignificant, and they are sufficiently deformable to enable tissue perfusion. However, in pathological conditions that are associated with low-flow states (e.g., trauma, ischemia), elevated plasma components (mainly fibrinogen), or altered RBC properties (e.g., hemoglobinopathies, oxidative stress, inflammation, diabetes), RBC flow properties are altered and present a circulatory risk.
AB - Red blood cells (RBC) have unique flow-affecting properties - namely, aggregability, deformability and adherence to endothelial cells (EC) - which play major roles in blood flow. Under normal flow-induced shear stress RBC are dispersed, their adherence to EC is insignificant, and they are sufficiently deformable to enable tissue perfusion. However, in pathological conditions that are associated with low-flow states (e.g., trauma, ischemia), elevated plasma components (mainly fibrinogen), or altered RBC properties (e.g., hemoglobinopathies, oxidative stress, inflammation, diabetes), RBC flow properties are altered and present a circulatory risk.
KW - Erythrocyte adherence
KW - Erythrocyte aggregation
KW - Erythrocyte deformation
UR - http://www.scopus.com/inward/record.url?scp=0142103876&partnerID=8YFLogxK
U2 - 10.1159/000073578
DO - 10.1159/000073578
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C2 - 13679654
AN - SCOPUS:0142103876
SN - 1424-8832
VL - 32
SP - 263
EP - 268
JO - Pathophysiology of Haemostasis and Thrombosis
JF - Pathophysiology of Haemostasis and Thrombosis
IS - 5-6
ER -
