The red blood cell in vascular occlusion

Saul Yedgar*, Alexander Koshkaryev, Gregory Barshtein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Red blood cells (RBC) have unique flow-affecting properties - namely, aggregability, deformability and adherence to endothelial cells (EC) - which play major roles in blood flow. Under normal flow-induced shear stress RBC are dispersed, their adherence to EC is insignificant, and they are sufficiently deformable to enable tissue perfusion. However, in pathological conditions that are associated with low-flow states (e.g., trauma, ischemia), elevated plasma components (mainly fibrinogen), or altered RBC properties (e.g., hemoglobinopathies, oxidative stress, inflammation, diabetes), RBC flow properties are altered and present a circulatory risk.

Original languageAmerican English
Pages (from-to)263-268
Number of pages6
JournalPathophysiology of Haemostasis and Thrombosis
Volume32
Issue number5-6
DOIs
StatePublished - 2002

Keywords

  • Erythrocyte adherence
  • Erythrocyte aggregation
  • Erythrocyte deformation

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