The redox status of malaria-infected erythrocytes: An overview with an emphasis on unresolved problems

The various mechanisms involved in the redox defence of norma erythrocytes are adequately known. They are herein briefly reviewed, outlining the principal enzymes metabolic pathways, such as superoxide dismutase, catalase, glutathione peroxidase reductase, the hexose monophosphate shunt (HMS) and glutathione synthesis and turnover. The intraerythrocytic malaria parasite is imposing an oxidative stress on its host cell. Malaria-infected cells produce O₂^-, H₂O₂, enhance lipide peroxidation and activate host cell HMS. This stress is produced during the digestion of host cell hemoglobin by the parasite. Hence, both parasite and host cell must be able to confront this stress. The antioxidant defence systems of the parasite and the response of those systems in the infected host cell are reviewed, underscoring unresolved problems. Nothing is virtually known on the parasite's glutathione metabolism, and on possible interactions between host cell and parasite antioxidant defence systems. The postulate that 1. host cell activated HMS in conjunction with purine salvage can provide purine nucleotides to the parasite, and 2. that glutathione transferase can participate in parasite resistance to antimalarial drugs, are also discussed.