TY - JOUR
T1 - The Regulatory Function of Poly(A) and Adjacent 3' Sequences in Translated RNA
AU - Littauer, Uriel Z.
AU - Soreq, Hermona
PY - 1982/1/1
Y1 - 1982/1/1
N2 - This chapter discusses the regulatory function of Poly(A) and adjacent 3' sequences in translated ribonucleic acids (RNAs). Messenger RNA chains from various biological sources contain, in addition to coding sequences, regions located at the 3' and 5' termini that are not translated. The nontranslated region at the 3' terminus is followed by a poly(A) segment of varying length. The chapter describes the properties and the possible regulatory functions of the nontranslated sequences and the poly(A) region located at the 3' termini of the RNA molecules. The poly(A) tails of various mRNAs are essentially similar in sequence and structure, and yet they seem to differ in their roles. Therefore, the difference among the stabilizing effects that these poly(A) tails confer on different mRNA species must be hidden elsewhere along the mRNA molecule. Also, the poly(A)-binding protein has a high affinity for binding sites in the nontranslated 3' sequence adjacent to the poly(A) segment. The chapter suggests that the role of the poly(A) tail is to stabilize translatable RNA chains by binding specific protein(s), provided that the properties of the adjacent 3' sequence favor such binding. The chapter describes the structure and function of 3'-terminal sequences in viral RNA. The chapter concludes with a discussion on the role of noncoding 3' sequences in translation and functional stability of mRNA.
AB - This chapter discusses the regulatory function of Poly(A) and adjacent 3' sequences in translated ribonucleic acids (RNAs). Messenger RNA chains from various biological sources contain, in addition to coding sequences, regions located at the 3' and 5' termini that are not translated. The nontranslated region at the 3' terminus is followed by a poly(A) segment of varying length. The chapter describes the properties and the possible regulatory functions of the nontranslated sequences and the poly(A) region located at the 3' termini of the RNA molecules. The poly(A) tails of various mRNAs are essentially similar in sequence and structure, and yet they seem to differ in their roles. Therefore, the difference among the stabilizing effects that these poly(A) tails confer on different mRNA species must be hidden elsewhere along the mRNA molecule. Also, the poly(A)-binding protein has a high affinity for binding sites in the nontranslated 3' sequence adjacent to the poly(A) segment. The chapter suggests that the role of the poly(A) tail is to stabilize translatable RNA chains by binding specific protein(s), provided that the properties of the adjacent 3' sequence favor such binding. The chapter describes the structure and function of 3'-terminal sequences in viral RNA. The chapter concludes with a discussion on the role of noncoding 3' sequences in translation and functional stability of mRNA.
UR - http://www.scopus.com/inward/record.url?scp=0020015358&partnerID=8YFLogxK
U2 - 10.1016/S0079-6603(08)60597-8
DO - 10.1016/S0079-6603(08)60597-8
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 7048421
AN - SCOPUS:0020015358
SN - 0079-6603
VL - 27
SP - 53
EP - 83
JO - Progress in Nucleic Acid Research and Molecular Biology
JF - Progress in Nucleic Acid Research and Molecular Biology
IS - C
ER -