Eosinophils are innate immune cells typically associated with allergic and parasitic diseases. However, in recent years, eosinophils have also been ascribed a role in keeping homeostasis and in fighting several infectious diseases. Indeed, these cells circulate as mature cells in the blood and can be quickly recruited to the infected tissue. Moreover, eosinophils have all the necessary cellular equipment such as pattern recognition receptors (PRRs), pro-inflammatory cytokines, anti-bacterial proteins, and DNA traps to fight pathogens and promote an efficient immune response. This review summarizes some of the updated information on the role of eosinophils' direct and indirect mediated interactions with pathogens.
Bibliographical noteFunding Information:
Prof. Levi-Schaffer's research is supported in part by the Emalie Gutterman Memorial Endowed Fund (USA), Israel Science Foundation (Moked grant no. 442/18), Aimwell Charitable Trust (UK), German-Israeli Foundation for Scientific Research and Development (grant no. I-1471-414.13/2018), and Rosetrees Charitable Trust (UK) (grant no. M416/A615). Prof. Levi-Schaffer is affiliated with the Adolph and Klara Brettler Center for Molecular Pharmacology and Therapeutics at the School of Pharmacy of The Hebrew University of Jerusalem.
© 2022 The Author(s). All rights reserved.