TY - JOUR
T1 - The relationship between drug release rate, particle size and swelling of silicone matrices
AU - Golomb, Gershon
AU - Fisher, Paula
AU - Rahamim, Ezra
PY - 1990/4
Y1 - 1990/4
N2 - Matrices composed of silicone elastomer (polydimethylsiloxane) have been used extensively as implantable controlled release drug delivery systems. This study examined the relationship between drug particle size, release rate and swelling of silastic matrices, by using a model drug (potassium dichromate) and two types of silicone polymer. The drug particles were found to be the driving force for water uptake by the matrix. The release rate was directly proportional to the degree of swelling, which in turn was directly proportional to the drug particle size. The release rate and swelling of matrices composed of silastic 382 increased with decreasing drug particle size, while increasing drug particle size resulted in increased release rate and decreased swelling of silastic Q7 matrices, probably because air is entrapped during fabrication of these matrices. More retarded release and swelling was exhibited by silastic Q7 matrices in comparison to matrices composed of silastic 382, probably due to the different physical properties of these silicones.
AB - Matrices composed of silicone elastomer (polydimethylsiloxane) have been used extensively as implantable controlled release drug delivery systems. This study examined the relationship between drug particle size, release rate and swelling of silastic matrices, by using a model drug (potassium dichromate) and two types of silicone polymer. The drug particles were found to be the driving force for water uptake by the matrix. The release rate was directly proportional to the degree of swelling, which in turn was directly proportional to the drug particle size. The release rate and swelling of matrices composed of silastic 382 increased with decreasing drug particle size, while increasing drug particle size resulted in increased release rate and decreased swelling of silastic Q7 matrices, probably because air is entrapped during fabrication of these matrices. More retarded release and swelling was exhibited by silastic Q7 matrices in comparison to matrices composed of silastic 382, probably due to the different physical properties of these silicones.
KW - drug release rate
KW - implantable systems
KW - silicons matrices
UR - http://www.scopus.com/inward/record.url?scp=0025269842&partnerID=8YFLogxK
U2 - 10.1016/0168-3659(90)90088-B
DO - 10.1016/0168-3659(90)90088-B
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AN - SCOPUS:0025269842
SN - 0168-3659
VL - 12
SP - 121
EP - 132
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2
ER -