The RNA-binding protein Vg1 RBP is required for cell migration during early neural development

Karina Yaniv, Abraham Fainsod, Chaya Kalcheim, Joel K. Yisraeli*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations

Abstract

After mid-blastula transition, populations of cells within the Xenopus embryo become motile. Using antisense morpholino oligonucleotides, we find that Vg1 RBP, an RNA-binding protein implicated in RNA localization in oocytes, is required for the migration of cells forming the roof plate of the neural tube and, subsequently, for neural crest migration. These cells are properly determined but remain at their site of origin. Consistent with a possible role in cell movement, Vg1 RBP asymmetrically localizes to extended processes in migrating neural crest cells. Given that Vg1 RBP is a member of the conserved VICKZ family of proteins, expressed in embryonic and neoplastic cells, these data shed light on the likely role of these RNA-binding proteins in regulating cell movements during both development and metastasis.

Original languageAmerican English
Pages (from-to)5649-5661
Number of pages13
JournalJournal of Embryology and Experimental Morphology
Volume130
Issue number23
DOIs
StatePublished - Dec 2003

Keywords

  • Cell movement
  • Neural crest
  • RNA-binding proteins
  • Roof plate
  • VICKZ protein family
  • Xenopus

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