The role of alternative splicing in cancer drug resistance

Zahava Siegfried, Rotem Karni

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations

Abstract

One of the major challenges in cancer treatment today is that many patients develop resistance to the therapeutic agents, resulting in treatment failure. Alternative splicing can significantly alter the coding region of drug targets. Here, we highlight several reports that provide key examples of alternative splicing events that occur in various cancers and play a role in resistance to cancer therapy. These examples present prime targets for future study and development of splicing modulation therapy. Modulation of alternative splicing has recently been approved as treatment for several diseases, although not yet for cancer. We propose that a similar approach may be successfully adapted to combat cancer therapy resistance, in cases where alternative splicing is known to be the mechanism that contributes to the resistance.

Original languageAmerican English
Pages (from-to)16-21
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume48
DOIs
StatePublished - Feb 2018

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

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