The role of bile acids in carcinogenesis

Philip R. Debruyne, Erik A. Bruyneel, Xuedong Li, Amazia Zimber, Christian Gespach, Marc M. Mareel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

167 Scopus citations

Abstract

Bile acids play a role in colorectal carcinogenesis as evidenced by epidemiological and experimental studies. Some bile acids stimulate growth of normal colonic and adenoma cells, but not of colorectal cancer cells. Moreover, bile acids stimulate invasion of colorectal cancer cells, at least in vitro. One possible mechanism of action is bile acid-induced DNA binding and transactivation of the activator protein-1 (AP-1) by co-operate activation of extracellular signal-regulated kinases (ERKs) and PKC signaling. In the present paper, we review the mechanisms by which bile acids influence carcinogenesis.

Original languageEnglish
Pages (from-to)359-369
Number of pages11
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume480-481
DOIs
StatePublished - 1 Sep 2001
Externally publishedYes

Keywords

  • Bile acids
  • Carcinogenesis
  • Invasion
  • Signaling

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