TY - JOUR
T1 - The role of dendritic inhibition in shaping the plasticity of excitatory synapses
AU - Bar-Ilan, Lital
AU - Gidon, Albert
AU - Segev, Idan
PY - 2012/12/19
Y1 - 2012/12/19
N2 - Using computational tools we explored the impact of local synaptic inhibition on the plasticity of excitatory synapses in dendrites. The latter critically depends on the intracellular concentration of calcium, which in turn, depends on membrane potential and thus on inhibitory activity in particular dendritic compartments. We systematically characterized the dependence of excitatory synaptic plasticity on dendritic morphology, loci and strength, as well as on the spatial distribution of inhibitory synapses and on the level of excitatory activity. Plasticity of excitatory synapses may attain three states: "protected" (unchanged), potentiated (LTP) or depressed (LTD). The transition between these three plasticity states could be finely tuned by synaptic inhibition with high spatial resolution. Strategic placement of inhibition could give rise to the co-existence of all three states over short dendritic branches. We compared the plasticity effect of the innervation patterns typical to different inhibitory subclasses - Chandelier, Basket, Martinotti and Double Bouquet - in a detailed model of a layer 5 pyramidal cell. Our study suggests that dendritic inhibition plays a key role in shaping and fine-tuning excitatory synaptic plasticity in dendrites.
AB - Using computational tools we explored the impact of local synaptic inhibition on the plasticity of excitatory synapses in dendrites. The latter critically depends on the intracellular concentration of calcium, which in turn, depends on membrane potential and thus on inhibitory activity in particular dendritic compartments. We systematically characterized the dependence of excitatory synaptic plasticity on dendritic morphology, loci and strength, as well as on the spatial distribution of inhibitory synapses and on the level of excitatory activity. Plasticity of excitatory synapses may attain three states: "protected" (unchanged), potentiated (LTP) or depressed (LTD). The transition between these three plasticity states could be finely tuned by synaptic inhibition with high spatial resolution. Strategic placement of inhibition could give rise to the co-existence of all three states over short dendritic branches. We compared the plasticity effect of the innervation patterns typical to different inhibitory subclasses - Chandelier, Basket, Martinotti and Double Bouquet - in a detailed model of a layer 5 pyramidal cell. Our study suggests that dendritic inhibition plays a key role in shaping and fine-tuning excitatory synaptic plasticity in dendrites.
KW - Compartmental model
KW - Dendritic cable
KW - Dendritic calcium
KW - Dendritic inhibition
KW - Synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=84872083986&partnerID=8YFLogxK
U2 - 10.3389/fncir.2012.00118
DO - 10.3389/fncir.2012.00118
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:84872083986
SN - 1662-5110
JO - Frontiers in Neural Circuits
JF - Frontiers in Neural Circuits
IS - DEC
ER -