Abstract
The somatic genomic methylation pattern which plays a role in the suppression of basal gene activity is established anew in each generation through developmentally regulated de novo and demethylation steps. Demethylation appears to be carried out by a nucleotide exchange reaction which may involve RNA molecules, and is directed to specific loci in the genome through interactions between cis acting elements and trans acting factors.
| Original language | English |
|---|---|
| Pages (from-to) | 481-486 |
| Number of pages | 6 |
| Journal | Genes to Cells |
| Volume | 2 |
| Issue number | 8 |
| DOIs | |
| State | Published - 1997 |