Abstract
Male Sprague-Dawley rats were injected with 1.5 mg/kg d-amphetamine and later sacrificed at a time when the locomotor activity induced by this dose of d-amphetamine was maximal (60 minutes post injection). Subsequently, both cortical and striatal slices were measured for 3H-DA and 3H-NE uptake. It was found that in vivo, d-amphetamine does not preferentially inhibit the reuptake of DA or NE in either the striatum or cerebral cortex, suggesting that any selective effect on a specific catecholamine must result from a mechanism other than selective uptake inhibition.
| Original language | English |
|---|---|
| Pages (from-to) | 333-335 |
| Number of pages | 3 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 35 |
| Issue number | 2 |
| State | Published - 1982 |