The role of dopamine and norepinephrine uptake inhibition in mediating the central effects of d-amphetamine in vivo

Male Sprague-Dawley rats were injected with 1.5 mg/kg d-amphetamine and later sacrificed at a time when the locomotor activity induced by this dose of d-amphetamine was maximal (60 minutes post injection). Subsequently, both cortical and striatal slices were measured for ³H-DA and ³H-NE uptake. It was found that in vivo, d-amphetamine does not preferentially inhibit the reuptake of DA or NE in either the striatum or cerebral cortex, suggesting that any selective effect on a specific catecholamine must result from a mechanism other than selective uptake inhibition.