The role of hypoxia-induced genes in ovarian angiogenesis

Rina Meidan*, Eyal Klipper, Yulia Zalman, Ronit Yalu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

The hypoxic microenvironment that occurs in fast-growing tissue such as the corpus luteum (CL) is a major contributor to its ability to survive via the induction of an intricate vascular network. Cellular responses to hypoxia are mediated by hypoxia-inducible factor-1 (HIF-1), an oxygen-regulated transcriptional activator. HIF-1, a heterodimer consisting of a constitutively-expressed β subunit and an oxygen-regulated α subunit, binds to the hypoxia responsive element (HRE) present in the promoter regions of responsive genes. This review summarises evidence for the involvement of hypoxia and HIF-1α in CL development and function. Special emphasis is given to hypoxia-induced, luteal cell-specific expression of multiple genes (vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF-2), prokineticin receptor 2 (PK-R2), stanniocalcin 1 (STC-1) and endothelin 2 (EDN-2) that participate in the angiogenic process during CL formation.

Original languageEnglish
Pages (from-to)343-350
Number of pages8
JournalReproduction, Fertility and Development
Volume25
Issue number2
DOIs
StatePublished - 2013

Keywords

  • basic fibroblast growth factor
  • corpus luteum
  • follicle
  • luteal endothelial cells
  • lutel steroidogenic cells
  • vascular endothelial growth factor.

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