TY - JOUR
T1 - The role of hypoxia-induced genes in ovarian angiogenesis
AU - Meidan, Rina
AU - Klipper, Eyal
AU - Zalman, Yulia
AU - Yalu, Ronit
PY - 2013
Y1 - 2013
N2 - The hypoxic microenvironment that occurs in fast-growing tissue such as the corpus luteum (CL) is a major contributor to its ability to survive via the induction of an intricate vascular network. Cellular responses to hypoxia are mediated by hypoxia-inducible factor-1 (HIF-1), an oxygen-regulated transcriptional activator. HIF-1, a heterodimer consisting of a constitutively-expressed β subunit and an oxygen-regulated α subunit, binds to the hypoxia responsive element (HRE) present in the promoter regions of responsive genes. This review summarises evidence for the involvement of hypoxia and HIF-1α in CL development and function. Special emphasis is given to hypoxia-induced, luteal cell-specific expression of multiple genes (vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF-2), prokineticin receptor 2 (PK-R2), stanniocalcin 1 (STC-1) and endothelin 2 (EDN-2) that participate in the angiogenic process during CL formation.
AB - The hypoxic microenvironment that occurs in fast-growing tissue such as the corpus luteum (CL) is a major contributor to its ability to survive via the induction of an intricate vascular network. Cellular responses to hypoxia are mediated by hypoxia-inducible factor-1 (HIF-1), an oxygen-regulated transcriptional activator. HIF-1, a heterodimer consisting of a constitutively-expressed β subunit and an oxygen-regulated α subunit, binds to the hypoxia responsive element (HRE) present in the promoter regions of responsive genes. This review summarises evidence for the involvement of hypoxia and HIF-1α in CL development and function. Special emphasis is given to hypoxia-induced, luteal cell-specific expression of multiple genes (vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF-2), prokineticin receptor 2 (PK-R2), stanniocalcin 1 (STC-1) and endothelin 2 (EDN-2) that participate in the angiogenic process during CL formation.
KW - basic fibroblast growth factor
KW - corpus luteum
KW - follicle
KW - luteal endothelial cells
KW - lutel steroidogenic cells
KW - vascular endothelial growth factor.
UR - http://www.scopus.com/inward/record.url?scp=84873854893&partnerID=8YFLogxK
U2 - 10.1071/RD12139
DO - 10.1071/RD12139
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C2 - 22950963
AN - SCOPUS:84873854893
SN - 1031-3613
VL - 25
SP - 343
EP - 350
JO - Reproduction, Fertility and Development
JF - Reproduction, Fertility and Development
IS - 2
ER -