The role of iron in beta amyloid toxicity

David Schubert*, Mordechai Chevion

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

152 Scopus citations

Abstract

There is evidence that oxidative damage plays a causative role in Alzheimer’s disease and amyloid β protein (Aβ) toxicity. Iron is frequently a potent facilitator of free radical production due to its ability to mediate the conversion of H2O2 to hydroxyl radicals via the Fenton reaction or by virtue of hypervalent iron compounds. It is shown here that iron facilitates Aβ toxicity to cultured cells.

Original languageEnglish
Pages (from-to)702-707
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume216
Issue number2
DOIs
StatePublished - 13 Nov 1995

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